"

欧洲杯2020赛程时间表app集于多款游戏为一体,是业内最顶尖原生app,欧洲杯2020赛程时间表非常注重玩家的游戏体验,专业的欧洲杯2020赛程时间表,值得您的信赖,期待您的加入!

                            
                            

                              "
                              Xuemei Cao, Xiao Liu, Hongda Li, Yumeng Fan, Jiabin Duan, Yi Liu, Qun He. Transcription factor CBF-1 is critical forcircadian gene expression by modulating WHITE COLLAR complex recruitment to thefrq locus. PLOS Genetics. DOI: 10.1371/journal.pgen.1007570
                              發布日期:2019-11-12 瀏覽次數:  信息來源:生物學院

                              Transcription factor CBF-1 is critical forcircadian gene expression by modulating WHITE COLLAR complex recruitment to thefrq locus

                              Xuemei Cao, Xiao Liu, Hongda Li, Yumeng Fan, Jiabin Duan, Yi Liu, Qun He

                               

                              PLOS Genetics

                              DOI: 10.1371/journal.pgen.1007570

                               

                              ABSTRACT

                              Transcription of the Neurospora crassa circadian clock gene frequency (frq) is an essentialprocess in the negative feedback loop that controls circadian rhythms. WHITE COLLAR 1(WC-1) and WHITE COLLAR 2 (WC-2) forms the WC complex (WCC) that is the main activatorof frq transcription by binding to its promoter. Here, we show that Centromere BindingFactor 1 (CBF-1) is a critical component of the N. crassa circadian clock by regulating frqtranscription. Deletion of cbf-1 resulted in long period and low amplitude rhythms, whereasoverexpression of CBF-1 abolished the circadian rhythms. Loss of CBF-1 resulted in WC-independentFRQ expression and suppression of WCC activity. As WCC, CBF-1 also bindsto the C-box at the frq promoter. Overexpression of CBF-1 impaired WCC binding to the Cboxto suppress frq transcription. Together, our results suggest that the proper level of CBF-1 is critical for circadian clock function by suppressing WC-independent FRQ expressionand by regulating WCC binding to the frq promoter.

                              【打印本頁】 【關閉本頁】
                              欧洲杯2020赛程时间表