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(the)Tj /F9 1 Tf 1.4684 0 Td [( )16()11(\n)]TJ /F8 1 Tf 2.1316 0 Td (mutant)Tj 3.1465 0 Td (at)Tj 0.9524 0 Td (the)Tj 1.4683 0 Td (molecular)Tj 4.218 0 Td (level,)Tj 2.2393 0 Td (we)Tj 1.3266 0 Td (introduced)Tj 4.6431 0 Td (a)Tj 0.652 0 Td (plasmid)Tj 3.3959 0 Td (that)Tj 1.7801 0 Td (carries)Tj 2.8687 0 Td (a)Tj 0.6519 0 Td (luciferase)Tj -31.9575 -1.3039 Td (reporter)Tj 3.5035 0 Td (construct)Tj 3.9799 0 Td (\()Tj /F9 1 Tf [(\n)-8()20(  )12()4( )]TJ /F8 1 Tf (\))Tj 3.4639 0 Td (into)Tj 1.8425 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 361.7007 583.5401 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 373.8897 579.0614 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (at)Tj 0.9524 0 Td (the)Tj /F9 1 Tf 1.474 0 Td [()18()-4(#)]TJ /F8 1 Tf 2.1147 0 Td (locus.)Tj 2.5114 0 Td (As)Tj 1.2643 0 Td (shown)Tj 2.8516 0 Td (in)Tj 0.83 0.64 0.02 0 k 1.0318 0 Td (Fig)Tj 1.4854 0 Td (1B)Tj 0 g (,)Tj 1.4967 0 Td (the)Tj -35.07 -1.2982 Td (bioluminescence)Tj 6.9335 0 Td (rhythm)Tj 3.2202 0 Td (of)Tj 1.0148 0 Td (the)Tj /F9 1 Tf 1.474 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 345.4866 570.5007 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 355.5212 566.0787 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (,)Tj /F9 1 Tf 0.4422 0 Td [(\n)-8()20(  )12()4( )]TJ /F8 1 Tf 2.7892 0 Td (strains)Tj 2.863 0 Td (was)Tj 1.7008 0 Td (of)Tj 1.0148 0 Td (very)Tj 1.9219 0 Td (low)Tj 1.6554 0 Td (amplitude)Tj 4.2859 0 Td (and)Tj 1.7292 0 Td (long)Tj -33.9531 -1.2982 Td (period)Tj 2.8346 0 Td (comparing)Tj 4.5694 0 Td (to)Tj 1.0262 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [($)-15(%)]TJ /F8 1 Tf (,)Tj /F9 1 Tf 1.4116 0 Td [(\n)-8()20(  )12()4( )]TJ /F8 1 Tf 2.7837 0 Td (strains.)Tj 3.0896 0 Td (Sequence)Tj 3.9741 0 Td (alignment)Tj 4.269 0 Td (revealed)Tj 3.5263 0 Td (that)Tj 1.7744 0 Td (the)Tj 1.4741 0 Td (helix-loop-)Tj -32.2013 -1.3039 Td (helix)Tj 2.1486 0 Td (\(HLH\))Tj 2.9707 0 Td (region)Tj 2.8063 0 Td (of)Tj 1.0148 0 Td (CBF-1)Tj 2.8176 0 Td (protein)Tj 3.1521 0 Td (is)Tj 0.8446 0 Td (highly)Tj 2.7099 0 Td (conserved)Tj 4.2633 0 Td (from)Tj 2.2054 0 Td (yeast)Tj 2.1883 0 Td (to)Tj 1.0261 0 Td (mammals)Tj 4.1556 0 Td (\()Tj 0.83 0.64 0.02 0 k (Fig)Tj 1.8198 0 Td (1C)Tj 0 g (\).)Tj -32.9269 -1.2983 Td (To)Tj 1.3379 0 Td (determine)Tj 4.3257 0 Td (how)Tj 1.9389 0 Td (CBF-1)Tj 2.8176 0 Td (influences)Tj 4.2745 0 Td (the)Tj 1.474 0 Td (circadian)Tj 3.9175 0 Td (clock,)Tj 2.5398 0 Td (we)Tj 1.3266 0 Td (examined)Tj 4.1272 0 Td (the)Tj 1.474 0 Td (FRQ)Tj 2.1147 0 Td (expression)Tj -32.8646 -1.2983 Td (profile)Tj 2.8403 0 Td (at)Tj 0.9524 0 Td (different)Tj 3.6567 0 Td (time)Tj 2.0239 0 Td (points)Tj 2.7213 0 Td (in)Tj 1.0374 0 Td (constant)Tj 3.6396 0 Td (darkness)Tj 3.7417 0 Td (\(DD\).)Tj 2.5965 0 Td (FRQ)Tj 2.1203 0 Td (protein)Tj 3.1521 0 Td (levels)Tj 2.3754 0 Td (were)Tj 2.1203 0 Td (lower)Tj 2.4548 0 Td (in)Tj -35.4327 -1.2982 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 233.8015 505.5307 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 245.9905 501.1086 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (than)Tj 2.0296 0 Td (in)Tj 1.0375 0 Td (the)Tj 1.4683 0 Td (wild-type)Tj 3.9912 0 Td (strain)Tj 2.5001 0 Td (in)Tj 1.0318 0 Td (DD.)Tj 1.9219 0 Td (Moreover,)Tj 4.3936 0 Td (the)Tj 1.4684 0 Td (peak)Tj 2.0919 0 Td (of)Tj 1.0148 0 Td (FRQ)Tj 2.1147 0 Td (protein)Tj 3.1577 0 Td (was)Tj -35.3193 -1.3039 Td (delayed)Tj 3.2541 0 Td (in)Tj 1.0375 0 Td (the)Tj /F9 1 Tf 1.4682 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 276.7181 492.548 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 288.907 488.0692 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (relative)Tj 3.1408 0 Td (to)Tj 1.0261 0 Td (the)Tj 1.4683 0 Td (wild-type)Tj 3.9912 0 Td (strain)Tj 2.5001 0 Td (\()Tj 0.83 0.64 0.02 0 k (Fig)Tj 1.8199 0 Td (1D)Tj 0 g (\),)Tj 1.9955 0 Td (which)Tj 2.6533 0 Td (is)Tj 0.8447 0 Td (consistent)Tj 4.2576 0 Td (with)Tj -35.0869 -1.2982 Td (its)Tj 1.1451 0 Td (long)Tj 1.9843 0 Td (period)Tj 2.8346 0 Td (phenotype.)Tj 4.6657 0 Td (The)Tj 1.7802 0 Td (levels)Tj 2.3754 0 Td (of)Tj /F9 1 Tf 1.0148 0 Td [(\n)-8()20( )]TJ /F8 1 Tf 1.3266 0 Td (mRNA)Tj 3.0784 0 Td (in)Tj 1.0375 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 446.2299 479.5086 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 458.4188 475.0866 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (were)Tj 2.126 0 Td (increased)Tj 3.9968 0 Td (in)Tj 1.0375 0 Td (DD)Tj -35.5008 -1.2982 Td (\()Tj 0.83 0.64 0.02 0 k (Fig)Tj 1.8198 0 Td (1E)Tj 0 g (\),)Tj 1.8312 0 Td (suggesting)Tj 4.3993 0 Td (that)Tj 1.7802 0 Td (CBF-1)Tj 2.8176 0 Td (suppresses)Tj /F9 1 Tf 4.4447 0 Td [(\n)-8()20( )]TJ /F8 1 Tf 1.3209 0 Td (transcription.)Tj 5.6579 0 Td (We)Tj 1.6101 0 Td (then)Tj 2.0182 0 Td (evaluated)Tj 3.9911 0 Td (FRQ)Tj 2.1147 0 Td (stability)Tj -33.8057 -1.3039 Td (after)Tj 2.0352 0 Td (the)Tj 1.4684 0 Td (addition)Tj 3.6 0 Td (of)Tj 1.0148 0 Td (the)Tj 1.4683 0 Td (protein)Tj 3.1521 0 Td (synthesis)Tj 3.8211 0 Td (inhibitor)Tj 3.7814 0 Td (cycloheximide)Tj 5.9979 0 Td (\(CHX\).)Tj 3.2088 0 Td (FRQ)Tj 2.1147 0 Td (stability)Tj 3.3562 0 Td (was)Tj -35.0189 -1.2983 Td (similar)Tj 2.9877 0 Td (in)Tj 1.0318 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 273.9968 440.5039 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 286.1858 436.0818 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5058 0 Td (and)Tj 1.7291 0 Td (the)Tj 1.4683 0 Td (wild-type)Tj 3.9912 0 Td (strain)Tj 2.5001 0 Td (\()Tj 0.83 0.64 0.02 0 k (S1)Tj 1.508 0 Td (Fig)Tj 0 g (\).)Tj 2.0466 0 Td (The)Tj 1.7802 0 Td (mechanism)Tj 4.8472 0 Td (that)Tj 1.7801 0 Td (results)Tj 2.8063 0 Td (in)Tj -35.5801 -1.2982 Td (low)Tj 1.6554 0 Td (FRQ)Tj 2.1146 0 Td (protein)Tj 3.1578 0 Td (levels)Tj 2.3697 0 Td (but)Tj 1.5533 0 Td (high)Tj /F9 1 Tf 2.0126 0 Td [(\n)-8()20( )]TJ /F8 1 Tf 1.321 0 Td (mRNA)Tj 3.084 0 Td (levels)Tj 2.3755 0 Td (in)Tj 1.0318 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 440.5606 427.5212 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 452.8062 423.0992 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (is)Tj 0.8447 0 Td (unknown,)Tj 4.3086 0 Td (but)Tj 1.5534 0 Td (these)Tj -34.486 -1.3039 Td (molecular)Tj 4.218 0 Td (data)Tj 1.9162 0 Td (indicate)Tj 3.4072 0 Td (that)Tj 1.7801 0 Td (the)Tj 1.4684 0 Td (circadian)Tj 3.9174 0 Td (clock)Tj 2.3131 0 Td (is)Tj 0.8504 0 Td (dampened)Tj 4.4447 0 Td (in)Tj 1.0317 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 487.2755 414.5385 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 499.5212 410.0598 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain)Tj 2.5001 0 Td (due)Tj 1.6951 0 Td (to)Tj -34.1458 -1.2982 Td (impaired)Tj 3.8437 0 Td (regulation)Tj 4.3143 0 Td (of)Tj /F9 1 Tf 1.0148 0 Td [(\n)-8()20( )]TJ /F8 1 Tf 1.321 0 Td (expression.)Tj ET Q q 1 j 1 J 0 w 11.9999 0 0 11.9999 200.0125 360 cm BT /F15 1 Tf 1 TL -0.0033 Tc 0 0 Td (Overexpression)Tj 6.7087 0 Td (of)Tj 1.0677 0 Td (CBF-1)Tj 2.9102 0 Td (leads)Tj 2.3245 0 Td (to)Tj 1.0771 0 Td (low)Tj 1.6961 0 Td (amplitude)Tj 4.5119 0 Td (rhythms)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 200.0125 342.9921 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (To)Tj 1.3379 0 Td (further)Tj 3.0274 0 Td (confirm)Tj 3.4469 0 Td (the)Tj 1.4683 0 Td (function)Tj 3.6283 0 Td (of)Tj 1.0148 0 Td (CBF-1)Tj 2.8177 0 Td (in)Tj 1.0318 0 Td (the)Tj 1.474 0 Td (circadian)Tj 3.9174 0 Td (clock,)Tj 2.5399 0 Td (a)Tj 0.6519 0 Td (construct)Tj 3.9798 0 Td (in)Tj 1.0375 0 Td (which)Tj 2.6476 0 Td (the)Tj -34.0212 -1.2982 Td (expression)Tj 4.4617 0 Td (of)Tj 1.0148 0 Td (Myc-tagged)Tj 4.9549 0 Td (CBF-1)Tj 2.8176 0 Td (is)Tj 0.8504 0 Td (driven)Tj 2.8119 0 Td (by)Tj 1.1849 0 Td (quinic)Tj 2.7609 0 Td (acid)Tj 1.8709 0 Td (\(QA\)-inducible)Tj /F9 1 Tf 6.4176 0 Td [( )3()]TJ /F8 1 Tf 1.9786 0 Td (promoter)Tj 4.0365 0 Td (was)Tj -35.1607 -1.2983 Td (introduced)Tj 4.6431 0 Td (to)Tj 1.0261 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 290.4377 321.4488 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 302.6834 317.0267 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain.)Tj 2.7269 0 Td (We)Tj 1.6044 0 Td (quantified)Tj 4.3086 0 Td (Myc-CBF-1)Tj 4.9436 0 Td (expression)Tj 4.4617 0 Td (in)Tj 1.0375 0 Td (growth)Tj 3.0727 0 Td (medium)Tj -32.4224 -1.3039 Td (containing)Tj 4.5241 0 Td (different)Tj 3.6567 0 Td (QA)Tj 1.6554 0 Td (concentrations)Tj 6.1794 0 Td (\(0)Tj 1.0318 0 Td (to)Tj 1.0261 0 Td (10)Tj ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 390.274 308.4661 cm BT /F17 1 Tf 1 TL -0.0053 Tc 0 0 Td [()]TJ /F8 1 Tf (2)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 400.3086 303.9874 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (M\).)Tj 1.678 0 Td (The)Tj 1.7802 0 Td (amount)Tj 3.3562 0 Td (of)Tj 1.0148 0 Td (Myc-CBF-1)Tj 4.9379 0 Td (with)Tj 1.9956 0 Td (10)Tj ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 557.4614 308.4661 cm BT /F17 1 Tf 1 TL -0.0053 Tc 0 0 Td [()]TJ /F8 1 Tf (7)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 200.0125 291.0047 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (M)Tj 1.1111 0 Td (QA)Tj 1.6498 0 Td (and)Tj 1.7291 0 Td (without)Tj 3.3335 0 Td (QA)Tj 1.6498 0 Td (\()Tj 0.83 0.64 0.02 0 k (S2A)Tj 2.194 0 Td (Fig)Tj 0 g (\))Tj 1.8198 0 Td (partially)Tj 3.4923 0 Td (restore)Tj 2.9763 0 Td (the)Tj 1.4684 0 Td (conidiation)Tj 4.8132 0 Td (rhythm)Tj 3.2201 0 Td (of)Tj /F9 1 Tf 1.0148 0 Td [( )16()11(\n)]TJ /F8 1 Tf 2.1316 0 Td (mutant)Tj 3.1465 0 Td (\()Tj 0.83 0.64 0.02 0 k (Fig)Tj -35.7503 -1.2982 Td (2A)Tj 0 g (\),)Tj 1.9445 0 Td (indicating)Tj 4.269 0 Td (that)Tj 1.7744 0 Td (the)Tj 1.474 0 Td (low)Tj 1.6555 0 Td (levels)Tj 2.3754 0 Td (of)Tj 1.0148 0 Td (Myc-CBF-1)Tj 4.9379 0 Td (partially)Tj 3.4866 0 Td (rescue)Tj 2.7552 0 Td (the)Tj 1.4684 0 Td (circadian)Tj 3.9174 0 Td (conidiation)Tj -31.0731 -1.3039 Td (defects)Tj 2.965 0 Td (of)Tj /F9 1 Tf 1.0148 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 258.9165 269.4614 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 271.1055 264.9826 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (strain.)Tj 2.7269 0 Td (The)Tj 1.7801 0 Td (conidiation)Tj 4.8189 0 Td (rhythm)Tj 3.2144 0 Td (of)Tj 1.0148 0 Td (the)Tj /F9 1 Tf 1.474 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 440.4472 269.4614 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 450.4818 264.9826 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (,)Tj 0.4422 0 Td (qa-Myc-CBF-1)Tj 6.2305 0 Td (strain)Tj 2.5001 0 Td (was)Tj -34.2195 -1.2982 Td (completed)Tj 4.405 0 Td (rescued)Tj 3.2768 0 Td (when)Tj 2.4038 0 Td (the)Tj 1.474 0 Td (QA)Tj 1.6497 0 Td (concentration)Tj 5.8167 0 Td (was)Tj 1.7008 0 Td (between)Tj 3.5263 0 Td (10)Tj ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 452.0692 256.422 cm BT /F17 1 Tf 1 TL -0.0053 Tc 0 0 Td [()]TJ /F8 1 Tf (6)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 462.1039 252 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (and)Tj 1.7291 0 Td (10)Tj ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 488.9196 256.422 cm BT /F17 1 Tf 1 TL -0.0053 Tc 0 0 Td [()]TJ /F8 1 Tf (4)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 498.9543 252 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (M)Tj 1.1111 0 Td (in)Tj 1.0318 0 Td (the)Tj 1.474 0 Td (medium.)Tj -33.5108 -1.2982 Td (QA)Tj 1.6497 0 Td (at)Tj 0.9525 0 Td (10)Tj ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 235.559 243.4393 cm BT /F17 1 Tf 1 TL -0.0053 Tc 0 0 Td [()]TJ /F8 1 Tf (3)Tj ET Q q 1 j 1 J 0 w 10 0 0 10 245.537 239.0173 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (M,)Tj 1.3379 0 Td (however,)Tj 3.8381 0 Td (resulted)Tj 3.4015 0 Td (in)Tj 1.0375 0 Td (a)Tj 0.652 0 Td (slow)Tj 2.0182 0 Td (growth)Tj 3.0728 0 Td (rate)Tj 1.7461 0 Td (and)Tj 1.7348 0 Td (arrhythmic)Tj 4.7111 0 Td (conidiation)Tj 4.8189 0 Td (rhythm)Tj 3.2201 0 Td (in)Tj -36.1414 -1.3039 Td (the)Tj /F9 1 Tf 1.4684 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 233.8015 230.4566 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 243.7795 225.9779 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (,)Tj 0.4478 0 Td (qa-Myc-CBF-1)Tj 6.2305 0 Td (strain)Tj 2.5002 0 Td (\()Tj 0.83 0.64 0.02 0 k (Fig)Tj 1.8198 0 Td (2A)Tj 0 g (\),)Tj 1.9446 0 Td (suggesting)Tj 4.3993 0 Td (that)Tj 1.7801 0 Td (the)Tj 1.4684 0 Td (proper)Tj 2.931 0 Td (level)Tj 2.0126 0 Td (of)Tj 1.0148 0 Td (CBF-1)Tj 2.8176 0 Td (is)Tj 0.8504 0 Td (critical)Tj -34.5937 -1.2982 Td (for)Tj 1.3833 0 Td (circadian)Tj 3.9173 0 Td (clock)Tj 2.3188 0 Td (function.)Tj -6.4232 -1.2983 Td (QA-inducible)Tj 5.7429 0 Td (gene)Tj 2.0806 0 Td (expression)Tj 4.4673 0 Td (was)Tj 1.6952 0 Td (known)Tj 3.0047 0 Td (to)Tj 1.0261 0 Td (be)Tj 1.1509 0 Td (suppressed)Tj 4.6091 0 Td (by)Tj 1.1848 0 Td (catabolites)Tj 4.4164 0 Td ([)Tj 0.83 0.64 0.02 0 k (38)Tj 0 g (].)Tj 2.0806 0 Td (To)Tj 1.3379 0 Td (deter-)Tj -33.9927 -1.3039 Td (mine)Tj 2.2734 0 Td (whether)Tj 3.4694 0 Td (the)Tj 1.4684 0 Td (leaky)Tj 2.2677 0 Td (expression)Tj 4.4617 0 Td (of)Tj 1.0091 0 Td (Myc-CBF-1)Tj 4.9379 0 Td (is)Tj 0.8448 0 Td (subjected)Tj 3.9628 0 Td (to)Tj 1.0204 0 Td (catabolite)Tj 4.0535 0 Td (repression,)Tj 4.5921 0 Td (we)Tj 1.3266 0 Td (eval-)Tj -35.6878 -1.2983 Td (uated)Tj 2.4321 0 Td (the)Tj 1.4683 0 Td (conidiation)Tj 4.8131 0 Td (rhythm)Tj 3.2202 0 Td (of)Tj 1.0148 0 Td (the)Tj /F9 1 Tf 1.4683 0 Td [( )16()11(\n)]TJ ET Q q 1 j 1 J 0 w 7.4999 0 0 6.6659 363.2881 178.4692 cm BT /F9 1 Tf 1 TL -0.0053 Tc 0 0 Td [(!)36(")]TJ ET Q q 1 j 1 J 0 w 10 0 0 10 373.3228 173.9905 cm BT /F8 1 Tf 1 TL -0.004 Tc 0 0 Td (,)Tj 0.4422 0 Td (qa-Myc-CBF-1)Tj 6.2305 0 Td (strain)Tj 2.5001 0 Td (in)Tj 1.0375 0 Td (different)Tj 3.6566 0 Td (concentrations)Tj -31.1978 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